MOFs Customization for Antibody Delivery
InquiryAs an innovative enterprise focusing on the field of biomedicine, CD Formulation has been committed to developing and providing more efficient and safer drug delivery solutions. In order to meet market demand, we provide metal-organic frameworks (MOFs) customization services, focusing on delivering antibody drugs to diseased sites accurately and efficiently, improving therapeutic effects and reducing side effects.
What Are MOFs?
Metal-organic frameworks (MOFs) are crystalline materials with a periodic network structure formed by interconnected metal ions or metal clusters and organic ligands. They possess high specific surface area, porosity, tunable pore size, and good chemical functionality, and thus have broad application potential in areas such as drug delivery, biomedical imaging, and sensing.
How Do We Prepare MOFs?
Types and Characteristics of MOFs We Can Develop
| Types of MOFs |
Characteristics |
| Zn-based MOFs |
Zn has strong coordination ability and can coordinately bond with a variety of organic ligands. Zn-based MOFs have good stability, high specific surface area and pore volume, and have a wide range of applications, including gas storage, catalysis, sensors and drug delivery. |
| Cu-based MOFs |
Cu has good redox properties and coordination capabilities, so Cu-based MOFs have wide applications in the fields of gas adsorption and separation, photoelectrochemistry and biomedicine. |
| Fe-based MOFs |
Fe-based MOFs have good magnetic properties and redox activity, and have good application prospects in the fields of magnetic materials, catalysts, and drug carriers. |
| Mn-based MOFs |
Mn-based MOFs have good stability and magnetic properties as well as low toxicity, so they have broad application prospects in the biomedical field. |
| Al-based MOFs |
Al-based MOFs have good thermal and chemical stability and are widely used in catalyst carriers, gas storage and adsorption and other fields. |
| MOFs Modification |
MOFs can also be compounded with other materials to form materials with multifunctional properties. For example, using antibodies to modify MOFs can achieve targeted therapy with MOFs loaded with drugs. |
During the preparation process, we can customize MOF according to customer needs, including selecting different metal ions and organic ligands, adjusting reaction conditions, etc., to obtain MOF with specific pore size, specific surface area and stability.
How to Load Antibodies into MOFs?
- Synthesize MOFs with specific functional groups to enable coordination bonding with antibodies
- Mix the antibody with the MOFs with active functional groups under appropriate conditions
- By controlling the reaction conditions (such as temperature, time and pH value), the antibody can fully combine with the MOFs
- Separate unbound free antibodies to obtain antibody-loaded MOFs
- Characterize and analyze the activity of the loaded MOFs to confirm the stability and activity of the antibody in the MOFs
Highlights of Our MOFs Customization Services
- Rich Experience and Technology Accumulation
Our team brings extensive hands-on experience in MOF and antibody research. With advanced equipment in our labs, we've developed proven techniques for efficiently synthesizing MOFs and effectively loading antibodies.
- Diversified Customization Services
CD Formulation can adapt to our process in multiple ways - by selecting different metal ions or organic ligands, adjusting reaction conditions, and more. This diversified approach lets us engineer MOFs with ideal structures and properties for each antibody payload.
- Efficient Antibody Loading Technology
Our optimized loading methods allow packing antibodies into MOFs at high concentrations without compromising their stability or bioactivity. This results in more potent therapeutic and diagnostic formulations compared to free antibodies.
- Strict Quality Control System
Throughout the process, we implement rigorous quality control to ensure the consistency and reliability of our MOF antibody products.
The MOFs customization services provided by CD Formulation is designed to deliver antibody drugs to the diseased site accurately and efficiently, improving the therapeutic effect and reducing side effects. We have rich experience and technology accumulation, and can provide customers with diversified customized services, efficient antibody loading technology and professional technical support. Through our MOF customization services, customers can maximize the efficacy of antibodies. If you have questions or need to inquire, please contact us!
References
- Alt K.; et al. Self-assembly of oriented antibody-decorated metal-organic framework nanocrystals for active-targeting applications. Adv Mater. 2022, 34(21): e2106607.
- Cherkasov V.R.; et al. Antibody-directed metal-organic framework nanoparticles for targeted drug delivery. Acta Biomater. 2020, 103:223-236.
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