Epigenomics Services

CD Formulation is committed to advancing the life sciences through the power of epigenomics services. Our services enable researchers to achieve the best results with the latest epigenetic technologies.

What is Epigenomics?

Epigenetics is the study of alterations in gene expression without changes in the DNA sequence^[1]. Therefore, fundamentally, epigenomics, is the study of the effects of chromatin structure, including higher order chromatin folding and attachment to the nuclear matrix, packaging of DNA around nucleosomes, covalent modifications of histone tails (acetylation, methylation, phosphorylation, ubiquitination), and DNA methylation, which are on the genetic material of a cell, known as the epigenome^[2]. DNA methylation, one of the most important epigenetic signature type and methods, is widely used in the study of disease development, exposure and response to environmental factors, development and differentiation, and disease markers. Therefore, the study of epigenomics, which regulates genome or gene expression, provides new research directions for new therapeutic approaches.

What We Offer?

In epigenomics, DNA methylation, one of the most important types and methods of epigenetic characteristics, is widely used in the various research fields. Therefore, our service is currently based on the DNA methylation method, which provides our customers with the following two platforms.

Methylation Sequencing Platform

Methylation modification exists widely in many organisms and is an epigenetic modification of the genome involved in the regulation of gene expression and modulation of chromatin structure^[2]. At present, the high-throughput sequencing technologies of DNA methylation mainly involve the following three types technologies: Whole Genome Methylation Sequencing (WGBS), Reduced Representation Bisulfite Sequencing (RRBS), Methylated DNA immunoprecipitation sequencing (MeDIP-Seq).

CD Formulation's services include but are not limited to:

5mC DNA methylation sequencing service

oxBS-seq service (oxidative bisulfite sequencing)

ctDNA sequencing service

MeDIP-Seq service (methylated DNA immunoprecipitation sequencing)

MeRIP-seq service(methylated RNA immunoprecipitation sequencing)

ATAC-seq service (assay for transposase-accessible chromatin sequencing)

RRBS service (reduced representation bisulfite sequencing)

WGBS service (whole genome bisulfite sequencing)

scWGBS service (single-cell whole genome bisulfite sequencing)

Target-BS service (target bisulfite sequencing)

sc-RBS service (single-cell reduced-representation bisulfite sequencing)

CUT&Tag service (cleavage under targets and tagmentation)

Methylation Chip Platform

ChIP is a technique for studying how proteins interact with DNA in living cells. Using the specificity of antigen-antibody reaction, it can truly reflect the binding status of protein factors and genomic DNA in vivo. Chip-seq technology is a technology that combines ChIP with NGS to obtain the DNA sequence bound to the target protein at one time, determine the binding distribution of the protein and the exact binding site.

Our platform offer:

Illumina protocol

Agilent protocol

Advantages of Our Services

Contact Us

CD Formulation focuses on epigenomics for many years, leading many omics research services. If you are interested in related services, please contact us to help you find solutions available for your research project.