Chitosan Nanocarrier Development for Peptide & Protein Delivery

With our expertise and advanced technology platform, CD Formulation can develop diverse types of chitosan-based nanocarriers to meet the specific requirements and goals of our clients. For over 20 years, we have partnered with biopharmaceutical companies to optimize complex biomolecule therapies using cutting-edge nanotechnology.

Advantages of Chitosan Nanocarriers in Drug Delivery

Derived from the natural polymer chitin, chitosan is biocompatible, biodegradable, mucoadhesive, and cost-effective, making it an ideal biomaterial for crafting nanocarriers to precisely deliver biologics. Chitosan nanocarriers have broad application prospects in the field of drug delivery and can be used to treat tumors, cardiovascular diseases, neurological diseases, etc.

CSO-based nanoparticles for drug delivery (Vong, L.B.; et al. 2022)

What Nanocarriers Can We Develop Using Chitosan?

• Chitosan Nanoparticles Development

Chitosan nanoparticles can encapsulate a variety of therapeutic agents, including peptides and proteins. We utilize polyvalent anions such as tripolyphosphate (TPP) to form chitosan into nanoparticles through ionic cross-linking technology. Moreover, we can meet your customization needs for nanoparticles in terms of size, surface charge, and surface modification to meet specific drug delivery requirements.

• Chitosan Hydrogels Development

Chitosan hydrogels are three-dimensional networks. Their versatility allows for the incorporation of bioactive molecules, making them suitable for various tissue engineering applications. At CD Formulation, through professional hydrogel technology, we combine chitosan and its derivatives to self-assemble with other polymers into nanogels. By optimizing the water content and consistency of nanocarriers, sustained release and prolonged drug action can be achieved. Furthermore, chitosan hydrogels can also be administered as injectable formulations to achieve localized and targeted delivery to specific disease sites.

• Chitosan Lipid Nanoparticles Development

Combining the advantages of chitosan and lipids, our chitosan lipid nanoparticles offer enhanced drug delivery capabilities. These nanocarriers consist of a chitosan core surrounded by a lipid shell. The lipid shell can be engineered to modulate drug release kinetics and improve cellular uptake, while the chitosan core offers protection and biocompatibility.

• Chitosan Nanofibers Development

Chitosan nanofibers provide a unique platform for peptide and protein delivery. The nanocarriers we developed through technologies such as electrospinning exhibit a high surface area to volume ratio, and their fibrous structure can promote cell adhesion, proliferation and tissue regeneration, making them suitable for use in tissue engineering or drug-loaded scaffolds for wound healing.

Our Nanocarrier Characterization Services

• Size, surface charge, and morphology analysis by DLS, SEM, and TEM.
• Surface chemistry evaluation by FTIR, XPS, and NMR spectroscopy.
• Drug loading quantification by HPLC and fluorescence spectroscopy.
• In vitro drug release kinetics research.
• Cytotoxicity, cell uptake, transmucosal permeation, and pharmacokinetic studies.
• Complete physicochemical analysis.

Highlights of Our Chitosan Nanocarrier Development Services

• Multidisciplinary team experience with diverse chitosan dosage forms across discovery to market.
• Chitosan nanocarriers customized to each drug's delivery challenges.
• Streamlined project management from early research through commercial manufacturing.
• Cost and time efficiencies over establishing independent development capabilities.

Chitosan nanocarriers represent transformative platforms to advance biologics delivery. At CD Formulation, we combine materials science expertise with custom engineering design to optimize chitosan systems tailored to your goals. To explore collaborating, contact our team today! Let's leverage the unique advantages of chitosan together to deliver the next generation of life-changing peptide, protein, and antibody treatments.