Cancer Cell Membrane-Coated Nanoparticle Development
InquiryCD Formulation is a leading nanoparticle engineering company dedicated to developing advanced drug delivery solutions. With our dedicated facilities and multidisciplinary team of scientists, we aim to design innovative carriers for targeted therapeutics. One area of expertise is our cancer cell membrane-coated nanoparticle development services. Through proprietary biomimetic fabrication methods, we produce biocompatible nanoparticles cloaked in cell membranes extracted from different cancer types.
How Do Cancer Cell Membrane-Coated NPs Deliver Drugs?
It is promising that cancer cell membrane-coated NPs will be a viable platform for targeted drug delivery in oncology. By extracting plasma membranes from cancer cells and enclosing drug payloads within nanoparticles, the membranes can act as camouflage to help the particles evade immune detection. When administered intravenously, the disguised nanoparticles maintain the targeting abilities of membrane proteins while the drug is released directly at tumor sites. This double targeting approach aims to improve delivery efficiency and therapeutic responses for anti-cancer agents.
Preparation and mechanism of cancer cell membrane-coated nanoparticles (Jin J.; et al. 2019)
How Do We Develop Cancer Cell Membrane-Coated NPs?
| Isolation of Membranes |
- We start by isolating membranes from the target cancer cell line using techniques like cell fractionation or membrane extraction.
- This process ensures the retention of specific surface proteins and markers associated with the target cancer cells.
|
| Preparing the Nanoparticle Core |
- We engineer nanoparticle cores from materials suitable for drug or therapy encapsulation.
- These nanoparticles can be made from lipids, polymers, or inorganic substances, depending on the desired properties and applications.
|
| Coating the Nanoparticles |
- We carefully coat isolated cancer cell membranes onto the nanoparticle core using methods such as membrane fusion, membrane extrusion, or sonication.
- The coating mimics the cancer cells' natural makeup, allowing the particles to look similar and potentially target cancer cells better in the body.
|
| NPs Characterization |
- We can thoroughly characterize cancer cell membrane-coated nanoparticles to assess their size, morphology, surface marker expression, and drug loading capacity.
- Techniques such as dynamic light scattering, transmission electron microscopy, flow cytometry, and spectroscopic analysis may be employed for characterization purposes.
|
Applications of Our Cancer Cell Membrane-Coated NP Development Services
By leveraging cell membrane biomimicry, we can develop nanoparticles to evade the immune system while retaining tumor targeting capabilities. The particles can be engineered to encapsulate and release therapeutic nucleic acids intracellularly for targeted cancer gene editing, silencing or immunotherapy.
Our membrane camouflage technology also shows promise for developing targeted imaging nanoparticles. Through encapsulation of imaging agents like magnetic, fluorescent, or radioactive contrast materials, our cancer cell membrane-coated nanoparticles can function as biomimetic carriers to non-invasively image tumors with high precision.
Advantages of Our Cancer Cell Membrane-Coated NP Development Services
- We have extensive experience in cell membrane bionics to develop biomimetic drug delivery tools to evade immune surveillance and enhance targeted delivery to tumors.
- We preserve membrane surface markers when preparing cancer cell membranes to facilitate cancer cell receptor-mediated uptake.
- Our customizable services are available for a variety of therapeutics, including genes, proteins, or imaging reagents, facilitating multimodal applications in precision oncology.
- Through our flexible development platform, we tailor membrane and core nanoparticles to meet our customers' performance requirements by selecting the right material, engineering the nanoparticles, and modifying their formulations.
At CD Formulation, clients can leverage our versatile platform technology and comprehensive suite of characterization and validation tools to create customized particulate systems tailored to their application needs, be it drug delivery, molecular imaging or another area of oncology. Contact us today to learn more about our cancer cell membrane-coated nanoparticle development services and how we can assist you in achieving your goals!
References
- Jin J.; et al. Human cancer cell membrane-coated biomimetic nanoparticles reduce fibroblast-mediated invasion and metastasis and induce T-cells. ACS Appl Mater Interfaces, 2019, 11(8): 7850-7861.
- Zhou Z.; et al. Research progress of cancer cell membrane coated nanoparticles for the diagnosis and therapy of breast cancer. Front Oncol. 2023, 13:1270407.
Related Services
