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Antibody Spray Development

Inquiry

Antibody spray is a preparation form in which antibody drugs are made into sprays. It has the advantages of convenient administration, high stability, and accurate dosage. It has good application prospects in preventing and treating viruses. CD Formulation has a professional pharmaceutical research team and technology platform, which can develop antibody spray formulations that meet the efficacy and safety of customers according to customer needs, including research on spray formulation, stability and quality control.

Why Are Antibodies Made into Spray?

  • Convenient administration

It is convenient and quick to use, can quickly and effectively cover the lesion, and improve the absorption efficiency and bioavailability of the drug.

  • High stability

Packaging in sealed containers such as sealed bottles or capsules can avoid the impact of external factors on drug stability.

  • Accurate dosage

Using digital nozzles and quantitative control systems, the amount and location of drug spraying can be precisely controlled.

  • Reduce Systemic Side Effects

Antibody spray minimizes systemic exposure to therapeutic agents, reducing the risk of systemic side effects.

Antibody Spray Preparation Process

Sprays refer to preparations containing a drug-containing solution, emulsion or suspension placed in a specially designed device. During use, the contents are released in the form of mist with the help of an appropriate atomization system for inhalation by the patient. Sprays generally consist of drugs, excipients, containers, atomization devices, etc.

  • Antibody Engineering

    Based on customer needs, CD Formulation can provide customers with antibody preparation services. You can also choose to provide your own antibodies, please ensure enough to meet the needs of the experiment.

  • Formulation Development

    In order to formulate the selected antibodies and excipients into stable and compatible spray formulations, CD Formulation's formulation experts will continuously optimize factors such as antibody concentration, surfactants, cosolvents, propellant systems, and pH values to ensure the final product is completeness and efficacious.

  • Atomization Device Design

    The design and development of appropriate nebulization devices is critical for effective drug delivery. We consider factors such as particle size, spray pattern and device ergonomics to achieve optimal nebulization and patient convenience.

  • Preparation Process

    The preparation process of aerosols has a great impact on the quality and stability of the product. We continuously optimize the preparation process and filling process, and conduct online control of filling volume differences, osmotic pressure, and sealing during the development process of aerosols.

  • Key Projects for Quality Control

    1. Minimum filling quantity
    2. Leak rate
    3. Content of main ingredient per puff
    4. Content uniformity
    5. Total number of shots per bottle
    6. Particle size or particle size distribution of droplets

Application Prospects of Antibody Spray

  • Combination Therapy

We could combine antibodies and other drugs in a spray, delivering different drugs simultaneously to improve treatment effectiveness and overcome drug resistance.

  • Therapeutic Applications

Antibody sprays have huge potential in a wide range of therapeutic areas including oncology, respiratory diseases, dermatology and autoimmune diseases. The versatility of this delivery system allows us to tailor antibody sprays to our customers to meet every need.

Advantages of Our Antibody Spray Development Services

  • Professional R&D team
  • Advanced production technology
  • Personalized service plan
  • Strict quality control
  • Quick response and cooperation

CD Formulation is committed to advancing antibody spray research and development, and we provide comprehensive services covering the entire process from concept to commercialization. Our team of experts has extensive knowledge of antibody engineering, formulation development and regulatory compliance and is committed to delivering innovative and effective solutions. If you are interested in exploring the potential of antibody sprays, please contact us!

References

  1. Lin Y.; et al. Nasal spray of neutralizing monoclonal antibody 35B5 confers potential prophylaxis against severe acute respiratory syndrome coronavirus 2 variants of concern: a small-scale clinical trial. Clin Infect Dis. 2023, 76(3): e336-e341.
  2. Chavda V.P.; et al. Nasal sprays for treating COVID-19: a scientific note. Pharmacol Rep. 2023, 75(2): 249-265.
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