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Antibody drugs, monoclonal antibodies, double antibodies, and ADCs, have developed rapidly in recent years, and there are many blockbuster products in the fields of tumors and autoimmune diseases. After binding to specific targets, antibody drugs exert their therapeutic effects through biological effects such as activation or blocking of cytokine signals, activation of the complement system, and cell killing. The activity measurement of antibody drugs is to measure the effectiveness and potency of drugs. It is an indispensable part of the antibody drug evaluation system. It is an important means to explore the drug mechanism of action (MOA) and provide the basis for drug IND declaration. CD Formulation provides a series of antibody drug in vitro activity tests to ensure that your antibody drug in vitro pharmacodynamic screening can proceed smoothly and ultimately obtain molecules with high-quality drug efficacy.
CD Formulation can provide multiple testing services such as complement dependent cytotoxicity (CDC) detection service, antibody internalization experimental services, antibody binding activity determination services, etc.
Complement dependent cytotoxicity (CDC) detection service: After the target cells with specific antigens bind to the corresponding antibodies, with the participation of complement, the target cell membrane is damaged, resulting in increased cell membrane permeability and cell death. Analysis of antibody-mediated CDC activity has become a crucial step in the development and quality control of antibody drugs.
Antibody internalization experimental services: Antibody-drug conjugates (ADC) are mainly composed of three parts: monoclonal antibodies, linkers and cytotoxins. Antibodies, as the "missiles" of ADC drugs, have targeting functions and can specifically recognize tumor cell surface antigens. After binding to cell surface antigens, they undergo endocytosis, bringing cytotoxins to tumor cells and exerting toxic effects. Since some antibodies may not be internalized by target cells after binding to antigens, the internalization ability of antibodies is an important indicator for early screening of ADC drugs. CD Formulation provides you with a diverse, efficient and stable antibody internalization experimental platform.
Antibody binding activity measurement service: The antibody specifically binds to the corresponding antigen, and then through a series of biological effects, the therapeutic effect of the antibody is exerted. Binding activity can directly reflect the ability of an antibody to bind to an antigen and is an important quality control indicator to ensure the effectiveness of antibody drugs. Currently commonly used detection methods are ELISA and flow cytometry.
Apoptosis detection service: Antibody drugs exert their anti-tumor activity by inducing apoptosis in tumor cells. Antibody drugs compete with growth factors for binding to receptors on the cell membrane surface, blocking the signal transmission process, thereby preventing cell growth and spread and inducing cell apoptosis. Apoptosis detection experiments help to study the anti-tumor mechanism of antibody drugs and provide important reference indicators for in vitro drug efficacy evaluation.
Cell proliferation inhibition testing service: The cell proliferation inhibition method evaluates the biological activity of monoclonal antibody drugs by measuring cell survival and proliferation after drug action. The cell proliferation inhibition method mainly evaluates the biological activity of the drug by detecting cell viability and reflecting cell proliferation or death after being treated with different concentrations of drugs in different culture systems.
CD Formulation has comprehensive in vitro efficacy evaluation services for antibody drugs to ensure that your antibody drug development project can proceed smoothly and ultimately obtain molecules with high-quality efficacy. If you have any relevant questions, please contact our staff and we will answer and serve you as soon as possible.