Solid Microneedles Development Services

Solid microneedles produce micron-sized channels by piercing the tip of the needle into the skin. After removal of the microneedle, a patch coated with drug is applied to the micropore and the drug enters directly into the skin layer through its use of a drug patch, thus increasing penetration. The drug is absorbed by capillaries, showing systemic effects, but of course it can also be used for local effects, with solid microneedles delivering the drug to the surface layer by passive diffusion. The method is relatively simple to operate and does not require the assembly of an external driver.

Fig.1 Diagram of a solid microneedle. (Rn et al., 2020)

Solid microneedles provide sufficient mechanical strength by selecting the microneedle material and geometry, and reduce the force required to insert the microneedle into the tissue by increasing the sharpness of the tip. Solid microneedles are made from a variety of materials, including silicon, metals, and non-degradable polymers. Solid microneedles are mainly pyramidal or conical in shape, with microneedle lengths ranging from 150 to 1000 microns.

Fig.2 Solid microneedles made of silicon, metal and polymers. (Kim et al., 2012)

Solid Microneedle Technology Services

CD Formulation offers solid microneedle technology services in combination with professional pharmacy experts and advanced laboratory medical equipment. We offer technologies and solutions that effectively guarantee drug delivery, as well as immediate after-sales service. The main services we provide include the following:

1. Provide Solutions for Solid Microneedles

• Selection of materials for the preparation of solid microneedles and methods for their preparation.
• Techniques for sealing the drug delivery site to prolong the penetration of the drug by extending the time of the micropore channel and avoiding the rapid healing of the skin to affect the efficacy of the drug.
• Regulation of the mechanical strength of solid microneedles.
• Provide reports on the dynamic recovery status of the skin due to the existence of individual differences, and more precise control of the dose administered.

2. Provide Safety Evaluation of Different Application Sites

Stimulate different parts of the skin such as forehead, forearm and abdomen, while adjusting the solid microneedle density, length, array size and other factors for safety evaluation. Thus, it helps customers to analyze and be able to find the most suitable drug delivery site and reasonable microneedle size design when delivering drugs through the use of solid microneedles.

Types of Drug Delivery

Our solid microneedle technology can be used to deliver vaccines, insulin, and other protein drugs.

If you have a requirement about our drug delivery technology services, please contact us by phone or email, our colleagues will reply to you within three working days.

References

1. Rn, A , et al. A review of recent advances in microneedle technology for transdermal drug delivery[J]. Journal of Drug Delivery Science and Technology, 2020, 59.
2. Kim, Yeu-Chun , et al. Prausnitz. Microneedles for drug and vaccine delivery[J]. Advanced drug delivery reviews, 2012, 64(14): 1547-1568.