Melting Point Test

CD Formulation, as a professional drug formulation development provider, offers a series of drug analysis and testing services, including the determination of physical constants, bioassays, impurity analysis, stability testing and method validation and development services, which help customers to know enough specific information about drugs for better drug development and accelerate the process of drug commercialization. In fact, the determination of the melting point of a drug can be used to analyze the purity of a drug, in addition to determining the properties of a newly developed drug.

About the Melting Point of Drugs

The determination of the melting point of a drug is a standard experimental procedure and is relatively simple. It is often used to identify a sample, determine its purity, and determine the thermal stability of the sample. When measuring the melting point, the temperature is usually recorded as the melting range rather than the exact melting point. This is because most samples seem to melt in a very small temperature range. The melting range is the difference between the temperature at which the sample begins to melt and the temperature at which the sample actually melts. In general, we use drug melting points to discern the purity of a drug by analyzing the characteristics of its melting point, e.g., pure samples usually have sharp melting points, while impure samples of the same compound melt at lower temperatures and over a wider range.

Melting Point Testing of Drugs

CD Formulation offers melting point analyzers that can safely test multiple samples simultaneously and can quickly help customers obtain melting point information for their drugs. Our common method is the capillary method, where a sample is placed in a capillary tube and experimented with, heating the sample until it reaches its melting point, which can then be recorded. Usually, the heating rate is reduced when the capillary is heated to near the melting point in order to observe when the sample melts. Observations are usually made through a viewing eyepiece. The melting point apparatus will most likely display the temperature in a digital format to facilitate recording of data.

Sample Preparation

First, ensure that the sample is completely dry and in powder form. Then, using a capillary tube, gently press the sample several times with the open end of the tube. The powder is then brought all the way to the bottom of the capillary by tapping the closed end several times on a hard surface in order to compact the sample at the closed end of the tube.

Caution When Testing Melting Points

• Do not remelt the sample! Always use fresh samples and new capillaries.
• Always use the same batch of capillary tubes for routine measurements. Not all capillaries are the same and using the same batch will ensure reproducible results.

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